Hi,
Sometime it happens that your destination become unaccessible. and hence Backup Job remove destination from its setting and hence does not run as per its schedule. To resolve this follow below steps.
1)Restart the vmware data recovery appliance
2) After restart, connect to VDR appliance from your vcenter client, Go to Backup Tab and Double Click the Backup Job you have created --> On Left hand side, click on Destination and on the right side select the destination which keeps your backup and clieck on Next.
3) Now Go to Configuration Tab --> On Left side, Click on Destination --> On Right side, Right click on the destination and then click Integrity Check.
This should resolve your issue and will start next backup schedule automatically .
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Thanks,
Sumit