Ciao
Yes, the changes affect the entire infrastructure but I advise you, if you have not done so, to read this KB carefully
https://kb.vmware.com/s/article/2149312
Where it is indicated that the first command
certutil -setreg DBFlags + DBFLAGS_ENABLEVOLATILEREQUESTS
has an impact on the infrastructure but a parameter must also be set within the certificate templates.
While the second command
certutil -setreg ca \ CRLFlags + CRLF_REVCHECK_IGNORE_OFFLINE
If your PKI is created correctly it may not be necessary. For this point, if you need I can give you more details and info.
Check the KB that I have indicated to you.